Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens.

Abstract

Selenite-induced cataractogenesis is mediated by oxidative stress leading to a decrease in the activity of Ca2+ ATPase, resulting in the accumulation of calcium and the subsequent activation of lenticular calpains. The results obtained indicated that Drevogenin D treatment was effective in protecting the lens proteins by controlling stress-induced protein oxidation, maintenance of Ca2+ ATPase activity, calcium accumulation, lipid peroxidation, and prevention of calpain activation. Hence, Drevogenin D can be used as a potential therapeutic agent against oxidative stress-induced cataract.