Concepedia

Severe respiratory changes at end stage in a FUS-induced disease state in adult rats

Kasey L. Jackson, Hemangini A. Dhaibar, Robert D. Dayton, Sergio Cananzi, William G. Mayhan, Edward Glasscock, Ronald L. Klein

BMC Neuroscience · 2016 · 10 citations · 45 references

DOI Full text

Open access

Abstract

This modeling method yields disease relevant motor and respiratory changes in adult rats. The reproducibility of the data supports the use of this method to study other disease related genes and their combinations as well as a platform for disease modifying interventional strategies.

References

45

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

Caroline Vance, Boris Rogelj, Tibor Hortobágyi et al. · Science · 2009 · 2.5K citations · Full text

Engineering, Genetics, Molecular Genetics +17

Mutations in the <i>FUS/TLS</i> Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

Thomas J. Kwiatkowski, Daryl A. Bosco, Aurélie Leclerc et al. · Science · 2009 · 2.5K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Somatic Variant +14

Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

Guangping Gao, Luk H. Vandenberghe, Mauricio R. Alvira et al. · Journal of Virology · 2004 · 1K citations · Full text

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Benjamin E. Deverman, Piers L. Pravdo, Bryan P. Simpson et al. · Nature Biotechnology · 2016 · 1K citations · Full text

Widespread Gene Transfer, Genetics, Neuroscience +5

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Clotilde Lagier‐Tourenne, Magdalini Polymenidou, Kasey R. Hutt et al. · Nature Neuroscience · 2012 · 732 citations · Full text

Protein Function, Amyotrophic Lateral Sclerosis, Natural Sciences +9