Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum

Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus

S. Morris Kupchan, Yasuo Komoda, William A. Court et al. · Journal of the American Chemical Society · 1972 · 432 citations

Medicine, Medicinal Chemistry, Pharmacology +6

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from <i>Actinosynnema</i> <i>pretiosum</i>

Tin‐Wein Yu, Linquan Bai, Dorothee Clade et al. · Proceedings of the National Academy of Sciences · 2002 · 286 citations · Full text

Life Sciences, Biochemistry, Microbiology +15

Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering

Dana Morrone, Luke Lowry, Mara K. Determan et al. · Applied Microbiology and Biotechnology · 2009 · 213 citations · Full text

Life Sciences, Biochemistry, Biotechnology +17

Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia

Eiji Higashide, Mitsuko Asai, Koichiro Ootsu et al. · Nature · 1977 · 213 citations

Medicine, Microbiology, Pharmacology +5

Increasing the efficiency of heterologous promoters in actinomycetes.

Christopher J. Wilkinson, Zoë A. Hughes‐Thomas, Christine Martin et al. · PubMed · 2002 · 185 citations

Life Sciences, Microbiology, Molecular Biology +16