Koichiro Ootsu

Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia

Eiji Higashide, Mitsuko Asai, Koichiro Ootsu et al. · Nature · 1977 · 212 citations

Antitumour Properties, Antibiotics, Antibiotic Adjuvant +8

Enhanced antitumor activity in mice after administration of thermosensitive liposome encapsulating cisplatin with hyperthermia.

Katsumi Iga, Naoru Hamaguchi, Yasutaka Igari et al. · Journal of Pharmacology and Experimental Therapeutics · 1991 · 38 citations

Non-glutamate Type Pyrrolo(2,3-d)pyrimidine Antifolates. I: Synthesis and Biological Properties of Pyrrolo(2,3-d)pyrimidine Antifolates Containing Tetrazole Congener of Glutamic Acid.

Fumio Itoh, K Yukishige, M. WAJIMA et al. · Chemical and Pharmaceutical Bulletin · 1995 · 31 citations · Full text

Non-glutamate Type Pyrrolo, Novel Dhfr Inhibitor, Glutamic Acid +13

Enhancement of anti-tumor activity of recombinant interleukin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2

Jun Sato, Naoru Hamaguchi, Kazuhiro Doken et al. · Biotherapy · 1993 · 30 citations

Medicine, Immunology, Immune Checkpoint Inhibitor +7

Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro.

Koichiro Ootsu, Yoshio Kozai, Masao Takeuchi et al. · PubMed · 1980 · 26 citations

New Antimitotic Antibiotics, Antitubulin Activities, Inhibit Tumor Growth +15