Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

Joshua B. Bederson, L H Pitts, Masahiko Tsuji et al. · Stroke · 1986 · 2.7K citations

Cerebrovascular Disease, Brain Circulation, Cerebral Vascular Regulation +22

Protective and therapeutic role for αB-crystallin in autoimmune demyelination

Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort et al. · Nature · 2007 · 499 citations

Autoimmune Disease, Autoantibody Production, Medicine +11

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

Lior Mayo, Sunia A. Trauger, Manon Blain et al. · Nature Medicine · 2014 · 460 citations · Full text

Inflammation, Astrocyte Activation, Glioma +12

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Minako Ito, Takashi Shichita, Masahiro Okada et al. · Nature Communications · 2015 · 410 citations · Full text

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

Wei Shao, Shuzhen Zhang, Mi Tang et al. · Nature · 2012 · 409 citations

Neurophysiology, Medicine, Neurotransmitter +10