Cyclophosphamide promotes the proliferation inhibition of mouse ovarian granulosa cells and premature ovarian failure by activating the lncRNA-Meg3-p53-p66Shc pathway

The p66shc adaptor protein controls oxidative stress response and life span in mammals

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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

Tanmoy Mondal, Santhilal Subhash, Roshan Vaid et al. · Nature Communications · 2015 · 686 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Activation of p53 by MEG3 Non-coding RNA

Yunli Zhou, Ying Zhong, Yingying Wang et al. · Journal of Biological Chemistry · 2007 · 650 citations · Full text

Medicine, Molecular Biology, Oncology +16

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Mirella Trinei, Marco Giorgio, Angelo Cicalese et al. · Oncogene · 2002 · 437 citations

Life Sciences, Cell Biology, Molecular Biology +17

Deletion of the p66 ^Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet

Claudio Napoli, Inés Martín-Padura, Filomena de Nigris et al. · Proceedings of the National Academy of Sciences · 2003 · 378 citations

Life Sciences, Biochemistry, Physiology +17