New England Journal of Medicine · 2016 · 1.8K citations · 5 references
Life SciencesGeneticsOncologyCancer GeneticsGenomicsMolecular OncologyCancer GenomicsClinical GenomicsDna SequencingGenomic Data IntegrationGenomics IntegrationNext-generation Sequencing In OncologyClinical Genomic Data IntegrationClinical Next-generation SequencingCross-platform Genomic HarmonizationData CommonsGenomic Data SharingInteroperable Genomic Data ModelsNext-generation Sequencing AnalysisProcess Harmonization
This FAIRsharing record describes: The National Cancer Institute’s (NCI’s) Genomic Data Commons (GDC) is a data sharing The National Cancer Institute's Genomic Data Commons (GDC) was created to promote precision medicine in oncology. It supports the import and standardization of genomic and clinical data from cancer research programs. The GDC contains NCI-generated data from some of the largest and most comprehensive cancer genomic datasets, including The Cancer Genome Atlas (TCGA) and Therapeutically Applicable Research to Generate Effective Therapies (TARGET). For the first time, these datasets have been harmonized using a common set of bioinformatics pipelines, so that the data can be directly compared. As a growing knowledge system for cancer, the GDC also enables researchers to submit data, and harmonizes these data for import into the GDC.
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Discovery and saturation analysis of cancer genes across 21 tumour types
Michael S. Lawrence, Petar Stojanov, Craig H. Mermel et al. · Nature · 2014 · 3.2K citations · Full text
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Combined Vemurafenib and Cobimetinib in <i>BRAF</i> -Mutated Melanoma
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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
Wyndham H. Wilson, Ryan M. Young, Roland Schmitz et al. · Nature Medicine · 2015 · 1.1K citations · Full text