Holographic tomography with scanning of illumination: space-domain reconstruction for spatially invariant accuracy

Abstract

The paper presents two novel, space-domain reconstruction algorithms for holographic tomography utilizing scanning of illumination and a fixed detector that is highly suitable for imaging of living biomedical specimens. The first proposed algorithm is an adaptation of the filtered backpropagation to the scanning illumination tomography. Its space-domain implementation enables avoiding the error-prone interpolation in the Fourier domain, which is a significant problem of the state-of-the-art tomographic algorithm. The second proposed algorithm is a modified version of the former, which ensures the spatially invariant reconstruction accuracy. The utility of the proposed algorithms is demonstrated with numerical simulations and experimental measurement of a cancer cell.