Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Jason M. Brenchley, David A. Price, Timothy W. Schacker, +17

Nature Medicine

Primary ImmunodeficiencyChronic Hiv InfectionAutoimmune DiseaseViral PersistenceHuman Retrovirus +10

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

David H. Munn, Min Zhou, John T. Attwood, +5

Science

A diverse range of gene products are effectors of the type I interferon antiviral response

John W. Schoggins, Sam J. Wilson, Maryline Panis, +4

Nature

PathogenesisImmunologyAntiviral ResponseAntiviral Drug DevelopmentVirology +6

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz, Ulrike Litzenburger, Felix Sahm, +16

Nature

Tumor BiologyOncogenic AgentMedicineEndogenous Tumour-promoting LigandReceptor (Biochemistry) +6

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

David H. Munn, Madhav Sharma, Babak Baban, +4

Immunity

Anergy InductionSignal TransductionReceptor Tyrosine KinaseT-regulatory CellImmune Regulation +10

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

John W. Schoggins, Donna A. MacDuff, Naoko Imanaka, +19

Nature

Host ResponseIfn-induced GenesPathogenesisImmunologyViral Pathogenesis +10

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

E. R. Pfefferkorn

Proceedings of the National Academy of Sciences

Interferon GammaParasitic DiseaseHost CellsAfrican TrypanosomiasisAntiparasitic Agent +13

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

David C. Goldstone, Valerie Ennis-Adeniran, Joseph J. Hedden, +12

Nature

Human RetrovirusImmunologyAntiviral ResponseMolecular BiologyVirology +3

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Thomas Pertel, Stéphane Hausmann, Damien Morger, +13

Nature

Virus StructureInnate Immune SensorHuman RetrovirusPathogenesisImmunology +6

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T _H 17 to Regulatory T Cells in HIV Disease

David Favre, Jeff E. Mold, Peter W. Hunt, +14

Science Translational Medicine

Hiv DiseaseT-regulatory CellImmunologyImmune RegulationImmunotherapy +19