Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation - Concepedia

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Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation

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Citations

44

References

2016

Year

Hossein Mohammad‐Beigi, Dina Morshedi, Seyed Abbas Shojaosadati, Jannik Nedergaard Pedersen, Amir Tayaranian Marvian, Farhang Aliakbari, Gunna Christiansen, Jan Skov Pedersen, Daniel E. Otzen

NanoparticlesMolecular BiologyNeurochemical BiomarkersSynaptic SignalingSocial SciencesProtein NanoparticlesPei-hsa-ga NpsDifferent Neurodegenerative DisordersNeurobiology Of DiseaseProtein FoldingSynaptic NeuroscienceUnfolded ConformationDegenerative PathologyProtein MisfoldingNeurologyNeuropathologyBiophysicsBiochemistry140-Residue Protein α-SynucleinMajor RoleGallic AcidNeurodegenerationNeurodegenerative DiseasesProteinopathiesDegenerative DiseaseNano-drug DeliveryMedicine

Abstract

The aggregation of the 140-residue protein α-synuclein (αSN) plays a major role in the pathogenesis of different neurodegenerative disorders such as Parkinson's Disease (PD).

References

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