Concepedia

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

Ulrike Garscha, Susanna Voelker, Simona Pace, Jana Gerstmeier, Besa Emini Veseli, Stefanie Liening, Antonietta Rossi, Christina Weinigel, Silke Rummler, Ulrich S. Schubert,

Biochemical Pharmacology · 2016 · 45 citations · 50 references

DOI

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References

50

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

Bengt Samuelsson · Science · 1983 · 2.9K citations

, , +14

Direct observation of individual endogenous protein complexes in situ by proximity ligation

Ola Söderberg, Mats Gullberg, Malin Jarvius et al. · Nature Methods · 2006 · 2.4K citations

, , +12

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

Anna Helgadóttir, Andrei Manolescu, Sólveig Grétarsdóttir et al. · Nature Genetics · 2004 · 926 citations · Full text

, , +12

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Tim Lämmermann, Philippe V. Afonso, B. Angermann et al. · Nature · 2013 · 922 citations · Full text

, , +14

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Richard A. F. Dixon, Ronald E. Diehl, Evan E. Opas et al. · Nature · 1990 · 776 citations

, , +10