Solution‐Phase Synthesis of the Macrocyclic Core of Teixobactin

Abstract

Towards the total chemical synthesis of the exceptionally potent antibiotic teixobactin, we synthesized the macrocyclic core of a natural product by using a solution‐phase approach. The gramscale synthesis of l ‐ allo ‐enduracididine and Shiina macrolactonization are highlights of the present disclosure.