Synthesis of β-Hydroxynaphthoate Derivatives from Ketodioxinones via Benzyne Acyl-Alkylation and Aldol Condensation Cascade

Abstract

A variety of highly functionalized β-hydroxynaphthoate derivatives are prepared by a two-step protocol: (1) acyl-alkylation of benzynes with ketodioxinones and (2) intramolecular aldol condensation. The substitution pattern of the products is related to polycyclic natural products derived from the type-II polyketide biosynthesis.