Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor

The kinetics of competitive radioligand binding predicted by the law of mass action.

Harvey Motulsky, L C Mahan · Molecular Pharmacology · 1984 · 419 citations

Medicine, Chemistry, Pharmacology +17

Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis

Yu Zhang, Liwei Lu, Caren Furlonger et al. · Nature Immunology · 2000 · 302 citations

Life Sciences, Hematology, Immunology +14

Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action.

Shitij Kapur, Philip Seeman · PubMed · 2000 · 284 citations

Medicine, Pharmacology, Psychiatry +14

Structural Optimization Affording 2-(<i>R</i>)-(1-(<i>R</i>)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(<i>S</i>)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss et al. · Journal of Medicinal Chemistry · 1998 · 205 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The role of binding kinetics in therapeutically useful drug action.

David C. Swinney · PubMed · 2009 · 189 citations

Pharmacy, Pharmacokinetics, Pharmacology +17