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New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms

HalogenationChromatinMedicinal ChemistryBiochemistryChromatin RemodelingNatural SciencesMolecular BiologyChemical BiologyMedicineHeavy Halogen AtomsNon-traditional ReplacementSmall MoleculesDrug Discovery