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Methotrexate increases glycogenolysis in the intact rat liver.
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1986
Year
Metabolic RemodelingM. GlycolysisOxidative StressMetabolic SyndromeHepatotoxicityMetabolic StateIntact Rat LiverHealth SciencesBiochemistryLiver PhysiologyInsulin ManagementGlucose ReleaseMetabolomicsPharmacologyLiverEnergy MetabolismHepatologyPhysiologyDiabetesCarbohydrate MetabolismLiver DiseaseMetabolismMedicine
The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected.