Efavirenz Inhibits the Human Ether‐A‐Go‐Go Related Current (hERG) and Induces QT Interval Prolongation in <i>CYP2B6*6*6</i> Allele Carriers

Abstract

This study demonstrates that homozygous carriers of CYP2B6*6 allele may be at increased risk for EFV-induced QTcF interval prolongation via inhibition of hERG.