NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart

Abstract

NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through the activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart.