Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery

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Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

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Life Sciences, Molecular Biology, Pharmacology +17

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

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Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

A.S. Dore, Krzysztof Okrasa, Jayesh C. Patel et al. · Nature · 2014 · 411 citations

Life Sciences, Molecular Biology, Neuroscience +12

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

Courtney S. Jernigan, Dharmendra B. Goswami, Mark C. Austin et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry · 2011 · 385 citations · Full text

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