Kathy Sengmany

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery

Kathy Sengmany, Junaid Singh, Gregory D. Stewart et al. · Neuropharmacology · 2016 · 52 citations

Medicine, Neuroscience, Pharmacology +16

Ligand-induced conformational changes in the β1-adrenergic receptor revealed by hydrogen-deuterium exchange mass spectrometry

Joanna Toporowska, Parth Kapoor, Maria Musgaard et al. · Nature Communications · 2024 · 28 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Kathy Sengmany, Shane D. Hellyer, Sabine Albold et al. · Neuropharmacology · 2019 · 24 citations · Full text

Medicine, Neuroscience, Pharmacology +16

Metabotropic glutamate receptor 5 (mGlu₅)‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu₅ signaling in recombinant cells and neurons

Shane D. Hellyer, Sabine Albold, Kathy Sengmany et al. · Journal of Neurochemistry · 2019 · 16 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site

Shane D. Hellyer, Kathy Sengmany, Andrew N. Keller et al. · Biochemical Pharmacology · 2020 · 16 citations

Life Sciences, Biochemistry, Neuroscience +17