Implementing Algorithm‐Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive <i>CYP2C9</i> and <i>VKORC1</i> Genetic Testing

Abstract

Implementation of pharmacogenetic-guided warfarin dosing has been hindered by inconsistent results from reported clinical trials and a lack of available algorithms that include alleles prevalent in non-white populations. However, current evidence indicates that algorithm-guided dosing is more accurate than empirical dosing. To facilitate multiethnic algorithm-guided warfarin dosing using preemptive genetic testing, we developed a strategy that accounts for the complexity of race and leverages electronic health records for algorithm variables and deploying point-of-care dose recommendations.