MedChemComm · 2016 · 24 citations · 89 references
MedicineMedicinal ChemistryPharmacologyAntimicrobial PharmacologyDrug DiscoveryEnzymologyAntibiotic ResistanceAntifungal AgentsAntifungal PharmacologyAntifungal ResistanceEnzyme InhibitionProtozoal InfectionsAminoacyl-trna SynthetasesAntiparasitic Drug DiscoveryClass Ii Aminoacyl-transfer Ribonucleic Acid SynthetasesFungal Enzyme InhibitorsHeterocyclic Natural ProductsInhibitor Design For Resistance EnzymesTransfer Rna (Trna) Chemistry
The tRNA synthetase enzymes are promising targets for development of therapeutic agents against infections by parasitic protozoans (<italic>e.g.</italic>malaria), fungi and yeast, as well as bacteria resistant to current antibiotics.
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Enzyme Structure with Two Catalytic Sites for Double-Sieve Selection of Substrate
Osamu Nureki, Dmitry G. Vassylyev, Masaru Tateno et al. · Science · 1998 · 320 citations