Studies of homograft sex and of gamma globulin phenotypes after orthotopic homotransplantation of the human liver.

Abstract

It has been established that several serum proteins synthesized exclusively by the liver convert in the recipient to the phenotype specificity of the original donor following orthotopic liver transplantation (1, 2, 3). In this study the gamma G globulins (IgG) which are normally thought to be nonhepatic in origin were examined in 10 human recipients of replacement livers. When it was unexpectedly found that the Gm types of the donor were transmitted to the recipient, histopathologic studies of the livers were carried out to determine their source.