Concepedia

TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN<sub>3</sub>

Yan He, Yuyang Xie, Ying‐Chun Wang, Xiaomin Bin, Dachao Hu, Heng‐Shan Wang, Ying‐Ming Pan

RSC Advances · 2016 · 22 citations · 51 references

DOI

Concepts

Abstract

A novel and efficient TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN<sub>3</sub><italic>via</italic> the radical mechanism process is described. A plausible reaction mechanism for this process is proposed.

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