Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca²⁺Influx Dysfunction in Human Pterygial Cells

Abstract

Mitogenic responses to EGF and VEGF are mediated through TRPV1 transactivation. Only in hPtEC do the increases in proliferation induced by EGF exceed those in HCjEC. Therefore, TRPV1 is a potential drug target whose clinical relevance in treating pterygium warrants further assessment.