2016 · 25 citations · 36 references
Life SciencesBioinformaticsGeneticsComputational BiologyGenomic Data AnalysisGenomicsDna SequencingGenome SequencingNext-generation SequencingVariant AnalysisComplexityExponential GrowthNext-generation Sequencing Data AnalysisParallel SequencingPopulation-level Variation
Breakthroughs in gene sequencing technologies have led to an exponential increase in the amount of genomic data. Efficient tools to rapidly process such large quantities of data are critical in the study of gene functions, diseases, evolution, and population variation. These tools are designed in an ad-hoc manner, and require extensive programmer effort to develop and optimize them. Often, such tools are written with the currently available data sizes in mind, and soon start to under perform due to the exponential growth in data. Furthermore, to obtain high-performance, these tools require parallel implementations, adding to the development complexity.
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Basic local alignment search tool
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