PubMed · 1976 · 14 citations · 0 references
MedicineNephrologyPharmacologyBone MetabolismDialysisHemodialysisBone Metabolism DisordersBone Metabolism PharmacotherapyDialysis PharmacotherapyRenal DiseaseRenal OsteodystrophyRenal PharmacologyBone Disorder In HemodialysisDialysis-related Bone DiseaseHepatic Microsomal MetabolismHydroxylationMicrosomal Enzyme ActivityOsteitis FibrosaRenal Adverse EffectsRenal Osteodystrophy Management
Two regular hemodialysis patients were assessed before, during and after therapy for 8 1/2 months with 1alpha-hydroxycholecalciferol (1alphaOHD3). The first patient (F.S.), treated with 2 mug daily, improved considerably with complete resolution of histological osteomalacia (O.M.), reduction in osteitis fibrosa (O.F.) and healing of Looser zones. The second patient (T.Y.), who was treated at the same time with a combination of phenobarbitone and phenytoin, showed no improvement while taking 3 mug of 1alphaOHD3 daily. It is suggested that hepatic microsomal enzyme inducing drugs antagonize the action of 1alphaOHD3 by interfering with its subsequent hepatic 25-hydroxylation.