PubMed · 1979 · 58 citations · 0 references
PharmacyPharmacologyDrug DiscoveryAssay DevelopmentEnzyme InhibitionEnzyme ScreeningHigh-throughput ScreeningDrug ScreeningEnzyme Inhibition ScreeningInhibitor ScreeningRapid Screening TestsReadoutUrea BiosensorsUrease ActivityUrease Inhibitors
Two methods are described that are suitable for the rapid screening of compounds as urease inhibitors. The first utilizes an electrode sensitive to NH4+ ions; the second is dependent on pH rise. A feature of both is a direct readout of reaction rate.