Platelet-tumor cell interaction.

Abstract

Several reports have appeared with regard to the potential role of platelets in tumor cells metastasis. Our in vitro studies with colon tumor cells in normals and in patients give some evidence against platelet aggregation as the determinant factor in tumor cell invasion and metastasis. Dimethylhydrazine induced colon tumors in Wistar rats demonstrate characteristic features of tumor cell dissociation in the invasion line and changes in intercellular adhesion.