Association of the OPRM1 and COMT genes’ polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?

COMT <i> val ¹⁵⁸ met </i> Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

Jon-Kar Zubieta, Mary M. Heitzeg, Yolanda R. Smith et al. · Science · 2003 · 1.1K citations

Life Sciences, Genetics, Neuroscience +17

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

Cherie E. Bond, K. Steven LaForge, Mingting Tian et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations

Medicine, Molecular Genetics, Pharmacology +17

Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G

Ying Zhang, Andrew D. Johnson, Audrey C. Papp et al. · Journal of Biological Chemistry · 2005 · 564 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Symptoms during cancer pain treatment following WHO-guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiology

Thomas Meuser, Christian Pietruck, Lukas Radbruch et al. · Pain · 2001 · 560 citations

Medicine, Oncology, Pharmacotherapy +17

The 118 A &gt; G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

Pål Klepstad, Trude Teoline Nausthaug Rakvåg, S. Kaasa et al. · Acta Anaesthesiologica Scandinavica · 2004 · 380 citations

Medicine, Genetics, Pharmacology +17