Use of chimeric muscarinic receptors to investigate epitopes involved in allosteric interactions.

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

Frederick J. Ehlert · Molecular Pharmacology · 1988 · 355 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.

R. Quirion, Paul A. Lapchak, R P Schaum et al. · PubMed · 1989 · 95 citations

Life Sciences, Neuroscience, Pharmacology +14

Two allosteric modulators interact at a common site on cardiac muscarinic receptors.

John E. Ellis, Margaret Seidenberg · Molecular Pharmacology · 1992 · 87 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors.

S Tucek, Jiřı́ Nedoma, Jan Proška et al. · Molecular Pharmacology · 1990 · 73 citations

Medicine, Biochemistry, Pharmacology +17

Chimeric m2/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis.

Jürgen Wess, T I Bonner, Mark R. Brann · Molecular Pharmacology · 1990 · 63 citations

Life Sciences, Neuroscience, Pharmacology +17