A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu et al. · Nature Biotechnology · 2012 · 999 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

Stephen C. Alley, Dennis R. Benjamin, Scott C. Jeffrey et al. · Bioconjugate Chemistry · 2008 · 465 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Robert P. Lyon, Jocelyn R. Setter, Tim D. Bovee et al. · Nature Biotechnology · 2014 · 445 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Bioanalytical Assay Strategies for The Development of Antibody–Drug Conjugate Biotherapeutics

Surinder Kaur, Keyang Xu, Ola M. Saad et al. · Bioanalysis · 2013 · 232 citations

Pharmacy, Oncology, Pharmacology +17

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Keyang Xu, Luna Liu, Ola M. Saad et al. · Analytical Biochemistry · 2011 · 191 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +12