Concepedia

Alemtuzumab as Antirejection Therapy

Anne P. Bouvy, Mariska Klepper, Michiel G.H. Betjes, Willem Weimar, Dennis A. Hesselink, Carla C. Baan

Transplantation Direct · 2016 · 19 citations · 37 references

DOIFull text

Open access

Abstract

Preliminary data from this small series suggest that alemtuzumab antirejection therapy induces homeostatic proliferation of memory and regulatory T cells with diminished responsiveness to the homeostatic cytokine IL-7. IL-2 responsiveness was affected in repopulated CD8+ T cells.

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