PubMed · 1980 · 71 citations · 0 references
Life SciencesBiochemistryPharmacologyDrug DeliveryEnzymologyLipid BiochemistryAntioxidant DefenseCell EncapsulationDrug EncapsulationLipid PeroxidationLiposomal FormulationsOxidative Damage To BiomoleculesCell Penetration MechanismsCellular Uptake Of LiposomesLipid-based EncapsulationLiposome CompositionLiposome Encapsulation Of ProteinsOxidative Damage To Cellular MembranesOxidative Damage To LipidsSuperoxide Dismutase Function
The fixation and penetration of liposomal encapsulated dismutase (SOD) with human erythrocytes and other eucaryote cells is described. Such preparations not only facilitate fixation and penetration of the enzyme as a function of liposome composition, but also confer an increased physiological life time as well as a marked organ specificity. Such packed SOD could be useful for a pharmacological application of the enzyme.