High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence

Donna D. Baird, David B. Dunson, Michael C. Hill, +2

American Journal of Obstetrics and Gynecology

Uterine FibroidsGynecological SurgeryHigh Cumulative IncidenceGynecologyPathology +4

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

S. E. Olpin

Nature Genetics

UrologyUterine FibroidsSomatic VariantGenitourinary CancerPathology +6

Inherited susceptibility to uterine leiomyomas and renal cell cancer

Virpi Launonen, Outi Vierimaa, Maija Kiuru, +6

Proceedings of the National Academy of Sciences

<i>MED12</i> , the <i>Mediator Complex Subunit 12</i> Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Netta Mäkinen, Miika Mehine, Jaana Tolvanen, +17

Science

Uterine LeiomyomasUterine FibroidsExome SequencingGeneticsMedicine +13

Characterization of Uterine Leiomyomas by Whole-Genome Sequencing

Miika Mehine, Eevi Kaasinen, Netta Mäkinen, +12

New England Journal of Medicine

Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

Chiara Bardella, Mona El‐Bahrawy, Norma Frizzell, +22

The Journal of Pathology

Genetic TestingMolecular BiologyPathologyDisease Gene IdentificationProtein Genetics +16

Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers

Miika Mehine, Eevi Kaasinen, Hanna-Riikka Heinonen, +12

Proceedings of the National Academy of Sciences

Distinct Driver PathwaysGynecologyPathologyCancer BiologyTumor Biology +15

<i>MED12</i> mutations in uterine fibroids—their relationship to cytogenetic subgroups

Dominique Nadine Markowski, Sabine Bartnitzke, Thomas Löning, +3

International Journal of Cancer

Recurrent Chromosomal AlterationsFibrosisUterine FibroidsSomatic VariantMed12 Mutations +6

Biallelic Inactivation of Fumarate Hydratase (FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors

Rainer Lehtonen, Maija Kiuru, Sakari Vanharanta, +18

American Journal Of Pathology

Biallelic InactivationFumarate HydratasePathologyGynecologyMedicine +3

Whole Exome Sequencing in a Random Sample of North American Women with Leiomyomas Identifies MED12 Mutations in Majority of Uterine Leiomyomas

Megan McGuire, Alexander N. Yatsenko, Lori Hoffner, +3

PLoS ONE

GeneticsPathologyGynecologyMolecular GeneticsDisease Gene Identification +16