Concepedia

Mediator Subunit Mutations

Mediator Subunit Mutations is a genetic alteration in one or more subunits of the Mediator complex, a multi-protein co-regulator of RNA polymerase II, that disrupts its structural integrity or functional interactions, thereby affecting transcriptional regulation and contributing to developmental disorders or diseases.

64

Publications

4K

Citations

497

Authors

210

Institutions

Publications per year

2017–2026

23

Parents

Publications

64

<i>MED12</i> , the <i>Mediator Complex Subunit 12</i> Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Netta Mäkinen, Miika Mehine, Jaana Tolvanen et al. · Science · 2011 · 660 citations

, , +17

Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers

Miika Mehine, Eevi Kaasinen, Hanna-Riikka Heinonen et al. · Proceedings of the National Academy of Sciences · 2016 · 230 citations · Full text

, , +17

Mediator protein mutations that selectively abolish activated transcription

Lawrence C. Myers, Claes M. Gustafsson, Kathleen Hayashibara et al. · Proceedings of the National Academy of Sciences · 1999 · 180 citations

, , +16

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: <i>In Vitro</i> and <i>In Vivo</i> Preclinical Models

Elayne Chan-Penebre, Kelli Armstrong, Allison E. Drew et al. · Molecular Cancer Therapeutics · 2017 · 168 citations

, , +17

Mediator as a General Transcription Factor

Yuichiro Takagi, Roger D. Kornberg · Journal of Biological Chemistry · 2005 · 165 citations · Full text

, , +17

1–5 of 64

Authors

497

  1. PV
    Pia Vahteristo

    University of Helsinki, Finland

    9 publications · 1.4K citations

    9

    h-index

  2. LA
    Lauri A. Aaltonen

    University of Helsinki, Finland

    6 publications · 1.2K citations

    6

    h-index

  3. NM
    Netta Mäkinen

    University of Helsinki, Finland

    6 publications · 1.3K citations

    6

    h-index

  4. RB
    Ralf Bützow

    Helsinki University Hospital, Finland

    6 publications · 683 citations

    6

    h-index

  5. MM
    Miika Mehine

    University of Helsinki, Finland

    5 publications · 1.1K citations

    5

    h-index

1–5 of 497

Institutions

210

  1. University of Helsinki

    Helsinki, Finland

    11 h-index

    97 publications

    18.9K citations

  2. Helsinki University Hospital

    Helsinki, Finland

    9 h-index

    31 publications

    4.2K citations

  3. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    4 h-index

    22 publications

    1.2K citations

  4. Northwestern University

    Evanston, United States

    3 h-index

    14 publications

    356 citations

  5. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    15 publications

    891 citations

  6. Stanford University

    Stanford, United States

    3 h-index

    9 publications

    1.4K citations

  7. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    4 publications

    556 citations

  8. Institute of Genetics and Developmental Biology

    Beijing, China

    3 h-index

    6 publications

    432 citations

1–8 of 210

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 591 citations

    5

    h-index

  2. Science

    2 publications · 778 citations

    2

    h-index

  3. American Journal of Medical Genetics Part A

    2 publications · 39 citations

    2

    h-index

  4. Nucleic Acids Research

    2 publications · 87 citations

    2

    h-index

  5. Molecular Human Reproduction

    MHR · 2 publications · 36 citations

    2

    h-index

1–5