PubMed · 1990 · 24 citations · 0 references
Veterinary MedicinePharmacotherapyToxicologyHepatologyHepatotoxicologyPoisoning ManagementAcute Liver FailureHepatic NecrosisHepatobiliary DiseaseHepatocellular NecrosisLiver DiseaseNecrosisAcute Hepatic NecrosisAcute Hepatocellular NecrosisDrug-induced Hepatic NecrosisDrug-induced Hepatocellular NecrosisHepatocellular ToxicitySubmassive Hepatic Necrosis
A 64-yr-old woman developed acute hepatitis after 3 wk of treatment with 40 mg/day of piroxicam (Feldene). Jaundice was preceded by a skin rash associated with eosinophilia. Despite withdrawal of the drug, she developed severe hepatocellular failure and died 53 days after the onset. Hepatitis was attributed to piroxicam because of the absence of other etiological factors.