Enhancing insulin oral absorption by using mucoadhesive nanoparticles loaded with LMWP-linked insulin conjugates

Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport

Constanze Hilgendorf, Hildegard Spahn‐Langguth, C G Regårdh et al. · Journal of Pharmaceutical Sciences · 2000 · 469 citations

Life Sciences, Biochemistry, Cell Biology +12

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

Lichen Yin, Jieying Ding, Chunbai He et al. · Biomaterials · 2009 · 447 citations

Pharmacy, Materials Science, Pharmaceutics +17

Overcoming the Diffusion Barrier of Mucus and Absorption Barrier of Epithelium by Self-Assembled Nanoparticles for Oral Delivery of Insulin

Wei Shan, Xi Zhu, Min Liu et al. · ACS Nano · 2015 · 388 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport

Isabel Behrens, Ana Isabel Vila Pena, Marı́a José Alonso et al. · Pharmaceutical Research · 2002 · 369 citations

Pharmacy, Materials Science, Pharmaceutics +17

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

Katharina Maisel, Laura M. Ensign, Mihika Reddy et al. · Journal of Controlled Release · 2014 · 311 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +17