Concepedia

Significance of Apparent Half-Lives of a Metabolite with a Higher Elimination Rate Than its Parent Drug

Tom B. Vree, Chiel A. Hekster, Eppo van der Kleijn

Drug Intelligence & Clinical Pharmacy · 1982 · 22 citations · 10 references

Concepts

PharmacyPharmacokineticsPharmacologyDrug ClearanceDrug MetabolismDrug DispositionDrug Half-lifeElimination KineticsHalf-life EstimationMetabolic ClearanceMetabolite KineticsDrug Elimination Half-lifeDrug Metabolite ClearanceDrug Metabolite EliminationEliminationMetabolic Half-lifeMetabolite PharmacokineticsTerminal Elimination Rate Constant

References

10

Pharmacokinetics and Bioavailability of Intravenous, Intramuscular, and Oral Lorazepam in Humans

David J. Greenblatt, Richard I. Shader, Käte Franke et al. · Journal of Pharmaceutical Sciences · 1979 · 198 citations

Pharmacy, Pharmacokinetics, Pharmacology +7

Progress in drug metabolism

Jason Hoult · FEBS Letters · 1978 · 126 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +12

Rapid Recovery From Massive Diazepam Overdose

David J. Greenblatt · JAMA · 1978 · 94 citations

Medicine, Pharmacokinetics, Pharmacology +10

Acetylation and deacetylation of the <i>p</i>-amino group of sulphonamide drugs in animal tissues

H. A. Krebs, W. O. Sykes, W Bartley · Biochemical Journal · 1947 · 61 citations · Full text

Life Sciences, Biochemistry, Pharmacology +5

Pharmacokinetics of Sulphamethoxazole in Man

T. B. Vree, Y. A. Hekster, A. M. Baars et al. · Clinical Pharmacokinetics · 1978 · 42 citations

Pharmacy, Pharmacokinetics, Pharmacology +3