<i><scp>IL</scp>‐33</i> polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort

Abstract

IL-33-polymorphisms rs928413 and rs1342326 may account for an increased risk of hay fever with the age of 6 years. Lower Tregs and increased SOCS3 in combined heterozygotes and minor allele homozygotes may be relevant for hay fever development, pointing towards dysbalanced immune regulation and insufficient control of allergic inflammation.