Concepedia

Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery

Guoyong Zhou, Yongmin Xu, Meiwan Chen, Du Cheng, Xintao Shuai

Polymer Chemistry · 2016 · 28 citations · 38 references

DOI

Concepts

Abstract

The pH-sensitive copolymer enhanced the lysosome escape of polyplexes and modification of iRGD endowed the polyplexes with effective intratumoral delivery and high transfection efficiency.

References

38

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

Kazuki N. Sugahara, Tambet Teesalu, Priya Karmali et al. · Science · 2010 · 1.1K citations · Full text

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Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte

Shutao Guo, Yuanyu Huang, Qiao Jiang et al. · ACS Nano · 2010 · 402 citations

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Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

Chunyang Sun, Song Shen, Cong‐Fei Xu et al. · Journal of the American Chemical Society · 2015 · 340 citations

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End‐functional polymers, thiocarbonylthio group removal/transformation and reversible addition–fragmentation–chain transfer (RAFT) polymerization

Ezio Rizzardo, San H. Thang · Polymer International · 2010 · 317 citations

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Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity <i>in Vivo</i>

Christopher E. Nelson, James R. Kintzing, Ann Hanna et al. · ACS Nano · 2013 · 289 citations

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