Concepedia

Polyplex Escape

Polyplex Escape is a synthetic gene delivery mechanism characterized by the release of polyplex nanoparticles from endosomal compartments into the cytosol, distinguished from other nucleic acid transport processes by its reliance on cationic polymers to facilitate membrane disruption and intracellular cargo release.

20

Publications

2.6K

Citations

109

Authors

35

Institutions

Publications per year

2017–2026

8

Parents

Publications

20

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

Rikke Vicki Benjaminsen, Maria Ahlm Mattebjerg, Jonas R. Henriksen et al. · Molecular Therapy · 2012 · 716 citations · Full text

, , +17

The great escape: how cationic polyplexes overcome the endosomal barrier

Tanja Buś, Anja Traeger, Ulrich S. Schubert · Journal of Materials Chemistry B · 2018 · 402 citations

, , +16

Endosomal Escape of Polymeric Gene Delivery Complexes Is Not Always Enhanced by Polymers Buffering at Low pH

Arjen M. Funhoff, Cornelus F. van Nostrum, Gerben A. Koning et al. · Biomacromolecules · 2003 · 268 citations

, , +17

Odd–Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles

Hirokuni Uchida, Kanjiro Miyata, Makoto Oba et al. · Journal of the American Chemical Society · 2011 · 213 citations

, , +15

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

Lotte Vermeulen, Toon Brans, Sangram Keshari Samal et al. · ACS Nano · 2018 · 210 citations · Full text

, , +16

1–5 of 20

Authors

109

  1. DJ
    Daan J.A. Crommelin

    Utrecht University, Netherlands

    2 publications · 356 citations

    2

    h-index

  2. DC
    Dawei Chen

    Shenyang Pharmaceutical University, China

    2 publications · 188 citations

    2

    h-index

  3. HH
    Haiyang Hu

    Shenyang Pharmaceutical University, China

    2 publications · 188 citations

    2

    h-index

  4. QW
    Qi Wang

    Zhejiang University, China

    2 publications · 188 citations

    2

    h-index

  5. WE
    Wim E. Hennink

    Utrecht University, Netherlands

    2 publications · 356 citations

    2

    h-index

1–5 of 109

Institutions

35

  1. Shanghai Jiao Tong University

    Shanghai, China

    2 h-index

    6 publications

    153 citations

  2. Institute of Chemistry

    Beijing, China

    2 h-index

    4 publications

    242 citations

  3. University of Science and Technology of China

    Hefei, China

    2 h-index

    4 publications

    123 citations

  4. Tianjin University

    Tianjin, China

    2 h-index

    5 publications

    429 citations

  5. Shenyang Pharmaceutical University

    Shenyang, China

    2 h-index

    16 publications

    1.5K citations

  6. Utrecht University

    Utrecht, The Netherlands

    2 h-index

    10 publications

    2K citations

  7. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    7 publications

    551 citations

  8. The University of Tokyo

    Tokyo, Japan

    2 h-index

    10 publications

    1.8K citations

1–8 of 35

Venues

  1. Biomacromolecules

    3 publications · 355 citations

    3

    h-index

  2. Journal of Materials Chemistry B

    2 publications · 434 citations

    2

    h-index

  3. Molecular Therapy

    1 publications · 716 citations

    1

    h-index

  4. The Journal of Chemical Physics

    1 publications · 108 citations

    1

    h-index

  5. Biomedicine & Pharmacotherapy

    1 publications · 11 citations

    1

    h-index

1–5