Dual c-Jun<i>N</i>-terminal kinase-cyclin D1 and extracellular signal-related kinase-c-Jun disjunction in human melanoma

Abstract

Dual disjunction between JNK-cyclin D1 and ERK-c-Jun signalling forms the basis for further investigation of combined JNK and MAPK signalling blockade as a more effective therapeutic approach in human melanoma.