Concepedia

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

Hong‐Min Ni, Mitchell R. McGill, Xiaojuan Chao, Kuo Du, Jessica A. Williams, Yuchao Xie, Hartmut Jaeschke, Wen‐Xing Ding

Journal of Hepatology · 2016 · 232 citations · 26 references

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Concepts

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26

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature · 2008 · 6.4K citations · Full text

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology · 2005 · 3.3K citations · Full text

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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

John R. Mitchell, David J. Jollow, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics · 1973 · 1.5K citations

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A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

Vladimir Kirkin, Trond Lamark, Yu‐shin Sou et al. · Molecular Cell · 2009 · 1.1K citations · Full text

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Mitchell R. McGill, Matthew R. Sharpe, C. David Williams et al. · Journal of Clinical Investigation · 2012 · 763 citations · Full text

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