Concepedia
British Journal of Pharmacology · 2016 · 67 citations · 53 references
Open access
Our results demonstrate that FAS activity is modulated in PH, and its inhibition may provide a new therapeutic approach to treat PH.
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza et al. · Cell Metabolism · 2006 · 3.8K citations · Full text
Reductive Stress, Signal Transduction, Biochemistry +11
Animal research: Reporting <i>in vivo</i> experiments: The ARRIVE guidelines
Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · British Journal of Pharmacology · 2010 · 3.6K citations · Full text
Cardiovascular Pharmacology, Pharmacotherapy, Experimental Pharmacology +18
Animal Research: Reporting <i>in vivo</i> Experiments—The ARRIVE Guidelines
Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · Journal of Cerebral Blood Flow & Metabolism · 2011 · 2K citations · Full text
Biology, Animal Testing, Plos Biology +12
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
Adam J Pawson, Joanna L Sharman, Helen E. Benson et al. · Nucleic Acids Research · 2013 · 854 citations · Full text
Drug Target, Iuphar Database, Pharmacotherapy +21
The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase
Paul F. Kantor, Arnaud Lucien, Raymond Kozak et al. · Circulation Research · 2000 · 802 citations
Heart Failure, Lipid Peroxidation, Metabolic Remodeling +17