PEBP4 silencing inhibits hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

Sylvia Grille, Alfonso Bellacosa, John J. Upson et al. · PubMed · 2003 · 617 citations

Medicine, Cell Biology, Oncology +17

Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

Peter Graham, Jinwei Hao, Jie Ni et al. · Cell Death and Disease · 2013 · 374 citations · Full text

Medicine, Oncology, Radiation Oncology +17

Activation of PI3K‐Akt signaling pathway promotes prostate cancer cell invasion

Sanjeev Shukla, Gregory T. MacLennan, Douglas J. Hartman et al. · International Journal of Cancer · 2007 · 314 citations

Medicine, Cell Biology, Oncology +16

Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT‐like phenotype change and MMP‐9‐mediated degradation of E‐cadherin

Jianhong Zuo, Wei Zhu, Maoyu Li et al. · Journal of Cellular Biochemistry · 2011 · 260 citations

Medicine, Cell Biology, Oncology +17

Expression of mTOR signaling pathway markers in prostate cancer progression

Celeste L. Kremer, Rob R. Klein, Jenny Mendelson et al. · The Prostate · 2006 · 183 citations

Medicine, Molecular Biology, Oncology +17