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Induction of Haemolysis and DNA Fragmentation in a Normal and Malarial-Infected Blood by Commonly - used Antimalarial Drugs in the North-Western Region of Nigeria

DOI

12

Citations

0

References

2016

Year

Aliyu Muhammad, Mohammed Auwal Ibrahim, Ochuko L. Erukaınure, Nathan Habila, Aimola Idowu, Uche Samuel Ndidi, Ibrahim Malami, Halliru Zailani, Zeenat Bello Kudan
Drug Metabolism Letters

Abstract

Commonly-used antimalarial drugs induced haemolysis and altered haemoglobin status which may spontaneously increases the cellular iron levels; a substrate for Fenton and Haber Weiss reactions, and eventually induces DNA fragmentation. Hence, adequate care should be taken during prescription with total avoidance for self medications and/or drugs abuse as a result of their adverse effects within the red blood cells and its immediate microenvironment.