Publication | Closed Access
Development of a Scalable Synthesis of Oxadiazole Based S1P<sub>1</sub> Receptor Agonists
36
Citations
9
References
2013
Year
Combinatorial ChemistryMolecular PharmacologyMedicinal ChemistryBioorganic ChemistryBiochemistryReaction ProductsNatural SciencesMedicineMechanism Of ActionPharmacological AgentOrganic ChemistryChemistryDrug DevelopmentS1p1 InhibitorsPharmacologyPharmaceutical ChemistryDrug DiscoveryScalable Synthesis
A robust and scalable synthesis was developed for the preparation of oxadiazole based S1P1 inhibitors. A new method for the separation of triphenylphosphine oxide from reaction products and an improved method for the synthesis of oxadiazoles in the presence of DBU were incorporated into the process to achieve its scalability.
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