Publication | Closed Access
Myosin Messenger RNA: Studies on Its Purification, Properties and Translation during Myogenesis in Culture
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1973
Year
Muscle FunctionGeneticsMolecular BiologyCytoskeletonMechanotransductionCellular PhysiologyProtein SynthesisEmbryo CultureSkeletal MuscleProtein FoldingMechanobiologyMolecular PhysiologyChick MuscleBiochemistryRna BiologyRna TransportGene ExpressionCell BiologyProtein BiosynthesisMyosin SynthesisDevelopmental BiologyMyosin Messenger RnaNatural SciencesCellular BiochemistryMedicineMyosin Heavy Chain
Although a great deal is known concerning the chemistry and function of the contractile proteins, it has been only recently that progress has been made in attempts to gain a detailed understanding of the biosynthesis of these proteins. It is our ultimate goal to elucidate the control mechanisms involved in myofibrillar protein synthesis, to understand the role of these mechanisms in the development of muscle, and to establish the relationship between the synthesis of these proteins and their ultimate assembly into the contractile apparatus. Although we are currently working on the synthesis of many of the structural proteins of chick muscle, the relative ease by which polysomes synthesizing myosin heavy chain can be isolated on sucrose density gradients (Heywood and Rich, 1968) has led us to analyze myosin synthesis in some detail.