ACS Applied Materials & Interfaces · 2015 · 42 citations · 35 references
PharmacyOncologyPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryTheranosticsCancer Drug DeliveryCancer NanomedicineNanocarriers For TherapeuticsNanomedicineNanoparticle Delivery SystemsNanoparticle FormulationsHyperthermiaLocalized Drug DeliveryMagnetic Drug Delivery SystemsMagnetic Nanoparticle Drug CarriersMagnetic Nanoparticle Drug DeliveryNanoparticle Cellular UptakeReverse-phase EvaporationTumor-targeted Drug Delivery
In this study, a new type of magnetic tumor-targeting PEGylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes was successfully obtained. The reverse-phase evaporation method was used to construct the magnetoliposomes, and then gold nanoshells were coated on the surface of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG2000 modification. This multifunction system was combined with a variety of functions, such as radiofrequency-triggered release, chemo-hyperthermia therapy, and dual-mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AuNSs-PEG complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosomal degradation. All results in vitro and in vivo indicated that DOX-TSMLs-AuNSs-PEG is a promising effective drug delivery system for diagnosis and treatment of tumors.
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Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy
Pallab Pradhan, Jyotsnendu Giri, Finn Rieken et al. · Journal of Controlled Release · 2009 · 465 citations · Full text
Pharmacy, Oncology, Pharmaceutics +12
Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery
Shan Jiang, Ahmed A. Eltoukhy, Kevin T. Love et al. · Nano Letters · 2013 · 233 citations · Full text